Inhibitory Control

The content of this page is only available in German. Please go to German version of this page.

Another thread of our recent work has been to understand the cognitive and neural computations underlying inhibitory control, the ability to stop or cancel inappropriate actions, which is known to be impaired in various psychiatric populations.

Beginning with a rational learning and decision-making model (Shenoy & Yu, 2011) that explained a wide range of puzzling behavioral and neural data related to inhibitory control, and compelling experimental results that validated our model (Ma & Yu, 2016), we then collaborated with Dr. C-S Li at Yale Medical School and Dr. M Paulus at UCSD Medical School to identify the neural correlates (in fMRI data) of probabilistic computation in the human brain (J. S. Ide, Shenoy, Yu*, & Li*, 2013), as well as investigating how the relevant cognitive and neural processes go awry psychiatric populations, in particular methamphetamine- and cocaine-users (Harlé et al., 2014, 2015; J. Ide, Hu, Zhang, Yu, & Li, 2015; Harlé, Zhang, Ma, Yu*, & Paulus*, 2016).

Related Papers

  • Shenoy, P & Yu, A J (2011). Rational decision-making in inhibitory control. Frontiers in Human Neuroscience 5:48. doi: 10.3389/fnhum.2011.00048.
  • Ide, J S, Shenoy, P, Yu*, A J, & Li*, C-R (2013). Bayesian prediction and evaluation in the anterior cingulate cortex. Journal of Neuroscience, 33: 2039-2047. *Co-senior authors.
  • Harlé, K M, Shenoy, P, Steward, J L, Tapert, S, Yu*, A J, & Paulus*, M P (2014). Altered neural processing of the need to stop in young adults at risk for stimulus dependence. Journal of Neuroscience, 34(13): 4567-4580. *Co-senior authors.
  • Haré, K M, Steward, J L, Zhang, S, Tapert, S, Yu*, A J, & Paulus*, M P (2015). Bayesian neural adjustment of inhibitory control predicts emergence of problem stimulant use. Brain, 138:3413-26. *Co-senior authors.
  • Harlé, K M, Zhang, S, Ma, N, Yu*, A J, & Paulus, M P* (2016). Reduced neural recruitment for Bayesian adjustment of inhibitory control in methamphetamine dependence Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 1: 448-459. *Co-senior authors.
  • Ma, N & Yu, A J (2016). Inseparability of Go and Stop in Inhibitory Control: Go Stimulus Discriminability Affects Stopping Behavior. Frontiers in Neuroscience.
  • Wang, W, Hu, S, Ide, J S, Zhornitsky, S, Zhang, S, Yu, A J, Li, C-S R (2018). Motor preparation disrupts proactive control in the stop signal task. Frontiers in Human Neuroscience, doi: 10.3389/fnhum.2018.00151.